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PBM Research276 studies

Photobiomodulation for Bone

276 peer-reviewed studies on light therapy for bone, spanning 1990 to 2020. Filtered from the full PBM database of 4,914 studies.

276

Total Studies

6

Human Studies

255

Positive Results

4

Wavelength Bands

Study Types

Rat
146 (53%)
In vitro
68 (25%)
Rabbit
34 (12%)
Review
15 (5%)
Human
6 (2%)
Animal
4 (1%)

Outcomes

positive
255 (92%)
unclear
17 (6%)
negative
4 (1%)

Wavelength Distribution

Near-IR (700-900nm)

150 studies

Not specified

58 studies

Red (600-700nm)

44 studies

IR (900nm+)

24 studies

All Studies (276)

Evidence from systematic reviews on photobiomodulation of human bone and stromal cells: Where do we stand?

ParentiArch Biochem Biophys2020
unclearIn vitro

Extracorporeal Shock-Wave Therapy or Low-Level Laser Therapy: Which is More Effective in Bone Healing in Bisphosphonate Treatment?

GölJ Craniofac Surg2020810nm
positiveRat

Marine collagen scaffolds and photobiomodulation on bone healing process in a model of calvaria defects.

CruzJ Bone Miner Metab2020808nm
positiveRat

Osteogenic Potential of Bovine Bone Graft in Combination with Laser Photobiomodulation: An Ex Vivo Demonstrative Study in Wistar Rats by Cross-Linked Studies Based on Synchrotron Microtomography and Histology.

LucaInt J Mol Sci2020808nm
positiveRat

Effect of laser photobiomodulation associated with a bioceramic cement on the repair of bone tissue in the femur of rats.

MacedoJ Photochem Photobiol B2020808nm
positiveRat

Photobiomodulation Therapy Associated with Heterologous Fibrin Biopolymer and Bovine Bone Matrix Helps to Reconstruct Long Bones.

RossoBiomolecules2020830nm
positiveRat

Raman spectroscopic study of the effect of the use of laser/LED phototherapy on the repair of complete tibial fracture treated with internal rigid fixation.

PinheiroPhotodiagnosis Photodyn Ther2020
positiveRabbit

Low-level laser therapy (LLLT) in sites grafted with osteoconductive bone substitutes improves osseointegration.

de OliveiraLasers Med Sci2020808nm
positiveRat

Photobiomodulation of human osteoblast-like cells in vitro by low-intensity pulsed LED light.

RosenbergFEBS Open Bio2020
positiveIn vitro

The effect of low-level laser radiation and doxycycline on the levels of osteoprotegerin and receptor activator of nuclear factor kappa-B ligand.

FarhadLasers Med Sci2020810nm
positiveIn vitro

Photobiomodulation guided healing in a sub-critical bone defect in calvarias of rats.

MagriLaser Ther2019808nm
positiveRat

The Effect of Photobiomodulation on Distraction Osteogenesis.

SarmadiJ Lasers Med Sci2019
unclearReview

Photobiomodulation Therapy (PBMT) Applied in Bone Reconstructive Surgery Using Bovine Bone Grafts: A Systematic Review.

RossoMaterials (Basel)2019
unclearReview

Photobiomodulation therapy (PBMT) in bone repair: A systematic review.

EscuderoInjury2019
unclearReview

Bioglass/PLGA associated to photobiomodulation: effects on the healing process in an experimental model of calvarial bone defect.

MagriJ Mater Sci Mater Med2019808nm
positiveRat

Evaluation of the Effects of Low-Level Laser Therapy on Diabetic Bone Healing.

DikerJ Craniofac Surg2019808nm
positiveRat

Effects of different settings for 940 nm diode laser on expanded suture in rats.

Tas DeynekAngle Orthod2019940nm
positiveRat

The influence of LLLT applied on applied on calvarial defect in rats under effect of cigarette smoke.

NunesJ Appl Oral Sci2019660nm
negativeRat

Histologic Evaluation of Early Bone Regeneration Treated with Simvastatin Associated with Low-Level Laser Therapy.

de MirandaInt J Oral Maxillofac Implants2019830nm
positiveRat

Low-level laser therapy enhances the number of osteocytes in calvaria bone defects of ovariectomized rats.

ScalizeAnimal Model Exp Med2019780nm
positiveRat

Effect of low-level laser therapy and zoledronic acid on bone repair process

BuchignaniLasers Med Sci2019808nm
positiveRat

Fibrin Sealant Derived from Human Plasma as a Scaffold for Bone Grafts Associated with Photobiomodulation Therapy.

PominiInt J Mol Sci2019830nm
positiveOther

Molecular impacts of photobiomodulation on bone regeneration: A systematic review.

HosseinpourProg Biophys Mol Biol2019
unclearReview

Effects of photobiomodulation in the treatment of fractures: a systematic review and meta-analysis of randomized clinical trials.

NetoLasers Med Sci2019
unclearReview

Histologic and Biomechanical Evaluation of Osseointegrated Miniscrew Implants Treated with Ozone Therapy and Photobiomodulation at Different Loading Times.

YücesoyInt J Oral Maxillofac Implants2019
positiveRabbit

The Effects of Photobiomodulation on MC3T3-E1 Cells via 630 nm and 810 nm Light-Emitting Diode.

ChangMed Sci Monit2019
positiveIn vitro

The effects of photobiomodulation therapy on mouse pre-osteoblast cell line MC3T3-E1 proliferation and apoptosis via miR-503/Wnt3a pathway.

LiLasers Med Sci2019808nm
positiveIn vitro

Effect of low power laser in biomodulation of cultured osteoblastic cells of Wistar rats1.

MorsoletoActa Cir Bras2019808nm
positiveIn vitro

A Comparative Study Between the Effectiveness of 980 nm Photobiomodulation Delivered by Hand-Piece With Gaussian vs. Flat-Top Profiles on Osteoblasts Maturation.

HannaFront Endocrinol (Lausanne)2019980nm
positiveIn vitro

Influence of low-level laser irradiation on osteocalcin protein and gene expression in bone tissue1.

BomfimActa Cir Bras.2018808nm
positiveRat

Association of Bioglass/Collagen/Magnesium composites and low level irradiation: effects on bone healing in a model of tibial defect in rats.

Gabbai-ArmelinLaser Ther2018808nm
positiveRat

Laser/LED phototherapy on the repair of tibial fracture treated with wire osteosynthesis evaluated by Raman spectroscopy.

PinheiroLasers Med Sci2018
positiveRabbit

Photobiomodulation Therapy in Bone Repair Associated with Bone Morphogenetic Proteins and Guided Bone Regeneration: A Histomorphometric Study

GerbiPhotomed Laser Surg2018830nm
positiveRat

Photobiomodulation on critical bone defects of rat calvaria: a systematic review.

BrassolattiLasers Med Sci2018
unclearReview

Evaluation of the Effects of Photobiomodulation on Partial Osteotomy in Streptozotocin-Induced Diabetes in Rats.

MostafaviniaPhotomed Laser Surg2018890nm
positiveRat

Investigation Of Effects Of Low Level Laser Therapy In Distraction Osteogenesis.

Gurler & GursoyJ Stomatol Oral Maxillofac Surg2018
positiveRabbit

Evaluation of photobiomodulation therapy associated with guided bone regeneration in critical size defects. In vivo study.

FreitasJ Appl Oral Sci2018808nm
positiveRat

Evaluation of bone repair after application of a norbixin membrane scaffold with and without laser photobiomodulation (λ 780 nm).

AlvesLasers Med Sci2018780nm
positiveRat

Effect of Low-Level Laser on the Healing of Bone Defects Filled with Autogenous Bone or Bioactive Glass: In Vivo Study.

MoreiraInt J Oral Maxillofac Implants2018780nm
positiveRat

Effect of low-level laser therapy on the healing of sites grafted with coagulum, deproteinized bovine bone, and biphasic ceramic made of hydroxyapatite and β-tricalcium phosphate. In vivo study in rats.

de OliveiraLasers Surg Med2018808nm
positiveRat

Determination of Optimum Operation Parameters for Low-Intensity Pulsed Ultrasound and Low-Level Laser Based Treatment to Induce Proliferation of Osteoblast and Fibroblast Cells.

CoskunPhotomed Laser Surg2018810nm
positiveIn vitro

The Combined Effects of Mesenchymal Stem Cell Conditioned Media and Low-Level Laser on Stereological and Biomechanical Parameter in Hypothyroidism Rat Model.

SefatiJ Lasers Med Sci2018890nm
positiveRat

Combined effect of recombinant human bone morphogenetic protein-2 and low level laser irradiation on bisphosphonate-treated osteoblasts.

JeongJ Korean Assoc Oral Maxillofac Surg2018808nm
positiveIn vitro

Combined Treatment with Low-Level Laser and rhBMP-2 Promotes Differentiation and Mineralization of Osteoblastic Cells under Hypoxic Stress.

HeoTissue Eng Regen Med2018808nm
positiveIn vitro

Effects of Nd:YAG low-level laser irradiation on cultured human osteoblasts migration and ATP production: in vitro study.

TsukaLasers Med Sci20181064nm
positiveIn vitro

Dose analysis of photobiomodulation therapy on osteoblast, osteoclast, and osteocyte.

NaJ Biomed Opt2018940nm
negativeIn vitro

Indocyanine green-mediated photobiomodulation on human osteoblast cells.

AteşLasers Med Sci2018809nm
positiveIn vitro

The impact of photobiomodulation on osteoblast-like cell: a review.

DeanaLasers Med Sci2018
unclearReview

Effects of 915 nm laser irradiation on human osteoblasts: a preliminary in vitro study.

MergoniLasers Med Sci2018915nm
positiveIn vitro

Long-Term Effect of Pulsed Nd-YAG Laser Combined with Exercise on Bone Mineral Density in Men with Osteopenia or Osteoporosis: 1 Year of Follow-Up

AlayatPhotomed Laser Surg20181064nm
negativeHuman
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